The U.S. Food and Drug Administration (FDA) recently expanded approval for Spravato (esketamine), a groundbreaking nasal ketamine spray, marking a significant advancement in depression treatments. Initially approved in 2019 for use alongside oral antidepressants, Spravato is now available as a standalone therapy for adults experiencing major depressive disorder (MDD) who have not adequately responded to traditional antidepressants.

What is Spravato?

Spravato is a nasal spray formulation of esketamine, closely related to ketamine, known for its rapid antidepressant effects. Unlike conventional oral antidepressants, which can take weeks to become effective, Spravato can significantly alleviate depressive symptoms within hours to days.

FDA Approval: Expanding Treatment Options

The recent FDA expansion in January 2025 makes Spravato more accessible for patients suffering from treatment-resistant depression. By permitting use without the mandatory pairing of an oral antidepressant, more patients can now benefit directly from its fast-acting relief.

Benefits of Nasal Ketamine (Spravato)

• Rapid symptom relief: Effective results often observed within hours.
• Accessibility: Standalone approval enhances accessibility for patients intolerant or unresponsive to oral antidepressants.
• Ease of administration: Simple nasal spray administered under healthcare supervision.

Potential Side Effects

Spravato is administered under professional medical supervision due to possible side effects, including:

• Dizziness
• Dissociative symptoms
• Increased blood pressure

Regular medical monitoring ensures patient safety and optimal therapeutic benefit.

Who Should Consider Spravato?

Patients with severe depression who have experienced limited success from traditional oral antidepressants might greatly benefit from Spravato. Consulting with a qualified psychiatrist will help determine suitability and establish an appropriate treatment plan.

How to Access Spravato Treatment

Interested patients should consult their psychiatrist or healthcare provider to discuss eligibility, potential benefits, and risks associated with Spravato.

Take Action Today

Are traditional antidepressants not working for you? Spravato could be the solution you’ve been looking for.

Schedule your consultation with a qualified psychiatrist today and discover if Spravato is right for you.